The program is a twelve-course one-year program that starts in August of each year with a kick-off / team building session and ends in August of the following year. Each month has a four-day session, usually from Thursday through Sunday, in which two classes are taught. Each class is taught for two consecutive months in two-day parts covering a total of 32 classroom hours. Additional contact hours with faculty are provided through videoconferencing and other electronic means.

During the twelve-month period the students must work on a team project to take a technology to market. From the first class, the students must select technologies that either they have brought from the workplace or that are provided by Mexican research centers and universities. During the program the students evaluate the potential of the technologies using the Quicklook™ methodology of the IC² Institute and build business plans and execution plans to develop a viable business.

The Masters / CTC was held in the CIMAV facility of the PIIT (Research and Technology Innovation Park) in Apodaca, Mexico (near Monterrey) for the first two-and-a-half years. Starting in April of 2011 the classes are held in the Center for Global Innovation and Entrepreneurship, the new facility of the University of Texas at Austin within the PIIT.